The present investigation aimed to develop and evaluate thermoreversible in-situ nasal gel containing curcumin nanoparticles. Curcumin nanoparticles were prepared by the ionic gelation method. These formulations were evaluated for entrapment efficiency, particle size, zeta potential and in-vitro drug release. Particle size and entrapment efficiency of the F1 formulation were found to be 299 nm and 83.1% respectively. Since the formulation, F1 showed a maximum amount of drug released in a controlled manner for a prolonged time. Hence F1 formulations were selected as optimized and further used for thermoreversible in-situ nasal gel by using 22 factorial designs. The thermoreversible nasal gel was evaluated for the gelation temperature (33°C) viscosity (10550cps) and spreadability (17.29±0.3 gm*cm/sec). Further, the prepared gel (FG3) was evaluated for an ex-vivo permeation study for 12 hours and it showed a maximum amount of drug release in a controlled manner. The % CDR of thermoreversible in-situ gel formulation FG3 was found to be 86.27% which follows the Higuchi model. The 'n' value of the formulation was found to be more than 0.5. This indicates that the release approximates the non-fickian diffusion mechanism.
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